Per an October 2014 interview with TVline, celebrating the 200th episode of the show, Jared Padalecki states 'Death's Door' is his favorite episode of the series thus far. Jensen Ackles revealed that it's also his favorite episode as well. Bobby is pushed into the trauma OR and a Dr. orders 80 grams of mannitol.

12 Funniest Supernatural Episodes to Watch or Rewatch

#1 The French Mistake  Season 6, Episode 15.
#2 Mystery Spot  Season 3, Episode 11.
#3 Changing Channels  Season 5, Episode 8.
#4 Fan Fiction  Season 10, Episode 5.
#5 Ghostfacers  Season 3, Episode 13.
#6 The Real Ghostbusters  Season 5, Episode 6.