Apart from analyzing other players, the only strategy that works is to play the big odds with the Martingale system. The odds must be more than 2.00, so doubling the bet after each loss is the only strategy that makes sense.
One unique feature of Aviator is the fact that it allows you to make two bets at once. This gives you an interesting way to try and balance out two contrasting bet types. For example, you could keep things safe by betting on a multiplier of 1.50, and then add an element of risk by betting on a multiplier of 5.00.