Yes, Bet365 is safe to use. The sportsbook provides various levels of firewall and other protections and the sportsbook itself is regulated by each of the state gaming regulations Bet365 is legal in.
Business operations are conducted from its headquarters in Stoke-on-Trent, alongside a satellite office in Malta. It was founded by Denise Coates, who remains the majority shareholder and joint-chief executive, alongside her brother John Coates.