You can register for DraftKings Casino in Michigan, Connecticut, New Jersey, West Virginia, or Pennsylvania. You can have an account for DraftKings Casino in other states, but you can't place a bet unless you are physically located in one of those legal markets.
Yes, you can bet online in West Virginia, as the state has legalized online casinos, online sportsbooks and online poker. Some of the best operators in the US allow WV bettors to play, including BetMGM, Caesars Palace Online Casino, DraftKings, FanDuel and BetRivers.